Here are the apps I typically run during the work day.

• Mail for email (duh).
• Safari for access to news and the CMS.
• TextExit for holding snippets of text and stripping styling when needed.
• Preview for re-sizing and cropping images [1. Occasionally I need to bust out Pixelmator, but 9 times out of 10 Preview is sufficient.].
• Colloquy for access to the TUAW “office.”
• Twitter for Mac for at-a-glance monitoring of multiple accounts. That little blue dot is a life saver.
• NetNewsWire Lite for RSS.

That’s pretty much all I need.